An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion

D. Klement, John; V. Paschall, Amy; S. Redd, Priscilla; L. Ibrahim, Mohammed; Lu, Chunwan; Yang, Dafeng; Celis, Esteban; I. Abrams, Scott; Ozato, Keiko; Liu, Kebin

doi:10.1172/jci123360

Public

An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion

Published in Journal of Clinical Investigation • Nov 4, 2018

Authors:

John D. Klement

Amy V. Paschall

Priscilla S. Redd

Abstract

Despite breakthroughs in immune checkpoint inhibitor (ICI) immunotherapy, not all human cancers respond to ICI immunotherapy and a large fraction of patients with the responsive types of cancers do not respond to current ICI immunotherapy. This clinical conundrum suggests that additional immune chec...

Subject

Osteopontin

Evasion (ethics)

Immune system

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