Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons

Xue, Yingchao; Zhan, Xiping; Sun, Shisheng; S. Karuppagounder, Senthilkumar; Xia, Shuli; L. Dawson, Valina; M. Dawson, Ted; Laterra, John; Zhang, Jianmin; Ying, Mingyao

doi:10.1002/sctm.18-0036

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Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons

Published in Stem Cells Translational Medicine • Nov 1, 2018

Authors:

Yingchao Xue

Xiping Zhan

Shisheng Sun

Abstract

Proneural transcription factors (TFs) drive highly efficient differentiation of pluripotent stem cells to lineage-specific neurons. However, current strategies mainly rely on genome-integrating viruses. Here, we used synthetic mRNAs coding two proneural TFs (Atoh1 and Ngn2) to differentiate induced ...

Subject

Dopaminergic

Cellular differentiation

Induced pluripotent stem cell

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