Critical Role of the UBL Domain in Stimulating the E3 Ubiquitin Ligase Activity of UHRF1 toward Chromatin.

BM, Foster; P, Stolz; CB, Mulholland; A, Montoya; H, Kramer; S, Bultmann; T, Bartke

doi:10.1016/j.molcel.2018.09.028

Public

Critical Role of the UBL Domain in Stimulating the E3 Ubiquitin Ligase Activity of UHRF1 toward Chromatin.

Shared by NobleBlocks on Nov 1, 2018 • 12:00 AM UTC

Authors:

Foster BM

Stolz P

Mulholland CB

Abstract

The RING E3 ubiquitin ligase UHRF1 controls DNA methylation through its ability to target the maintenance DNA methyltransferase DNMT1 to newly replicated chromatin. DNMT1 recruitment relies on ubiquitylation of histone H3 by UHRF1; however, how UHRF1 deposits ubiquitin onto the histone is unknown. H...

Subject

DNA methylation

Ubiquitylation

histone modification

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