<i>Campylobacter jejuni</i> promotes colorectal tumorigenesis through the action of cytolethal distending toxin

He, Zhen; Z. Gharaibeh, Raad; C. Newsome, Rachel; L Pope, Jllian; W. Dougherty, Michael; Tomkovich, Sarah; J. Pons, Benoît; Mirey, Gladys; Vignard, Julien; R. Hendrixson, David; Jobin, Christian

doi:10.1136/gutjnl-2018-317200

Public

Campylobacter jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxin

Published in Gut • Oct 30, 2018

Authors:

Zhen He

Raad Z. Gharaibeh

Rachel C. Newsome

Abstract

Objective Campylobacter jejuni produces a genotoxin, cytolethal distending toxin (CDT), which has DNAse activity and causes DNA double-strand breaks. Although C. jejuni infection has been shown to promote intestinal inflammation, the impact of this bacterium on carcinogenesis has never been examined...

Subject

Cytolethal distending toxin

Toxin

Campylobacter jejuni

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