Frequent Homologous Recombination Deficiency in High-grade Endometrial Carcinomas

M. de Jonge, Marthe; Auguste, Aurélie; M. van Wijk, Lise; C. Schouten, Philip; Meijers, Matty; T. ter Haar, Natalja; T.H.B.M. Smit, Vincent; A. Nout, Remi; A. Glaire, Mark; N. Church, David; Vrieling, Harry; Job, Bastien; Boursin, Yannick; D. de Kroon, Cor; Rouleau, Étienne; Léary, Alexandra; P.G. Vreeswijk, Maaike; Bosse, Tjalling

doi:10.1158/1078-0432.ccr-18-1443

Public

Frequent Homologous Recombination Deficiency in High-grade Endometrial Carcinomas

Published in Clinical Cancer Research • Nov 9, 2018

Authors:

Marthe M. de Jonge

Aurélie Auguste

Lise M. van Wijk

Abstract

Abstract Purpose: The elevated levels of somatic copy-number alterations (SCNAs) in a subset of high-risk endometrial cancers are suggestive of defects in pathways governing genome integrity. We sought to assess the prevalence of homologous recombination deficiency (HRD) in endometrial cancers and i...

Subject

Homologous chromosome

Homologous recombination

Endometrial cancer

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