Enhanced detection of circulating tumor DNA by fragment size analysis

Moulière, Florent; Chandrananda, Dineika; Piskorz, Anna; Moore, Elizabeth; Morris, James; Barlebo Ahlborn, Lise; Mair, Richard; Goranova, Teodora; Marass, Francesco; Heider, Katrin; C. M. Wan, Jonathan; Supernat, Anna; Hudecova, Irena; Gounaris, Ioannis; R�os, Susana; Jimenez‐Liñan, Mercedes; García-Corbacho, Javier; Patel, Keval; Østrup, Oľga; Murphy, Suzanne; Eldridge, Matthew; Gale, Davina; D. Stewart, Grant; Burge, Johanna; N. Cooper, Wendy; S. van der Heijden, Michiel; Massie, Charles; Watts, Colin; Corrie, Pippa; Pacey, Simon; M. Brindle, Kevin; D. Baird, Richard; Mau‐Sørensen, Morten; Parkinson, Christine; G. Smith, Christopher; D. Brenton, James; Rosenfeld, Nitzan

doi:10.1126/scitranslmed.aat4921

Public

Enhanced detection of circulating tumor DNA by fragment size analysis

Published in Science Translational Medicine • Nov 7, 2018

Authors:

Florent Moulière

Dineika Chandrananda

Anna Piskorz

Abstract

Existing methods to improve detection of circulating tumor DNA (ctDNA) have focused on genomic alterations but have rarely considered the biological properties of plasma cell-free DNA (cfDNA). We hypothesized that differences in fragment lengths of circulating DNA could be exploited to enhance sensi...

Subject

Fragment (logic)

DNA

In silico

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