Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis

Wu, Yunshu; Xie, Liang; Wang, Mengyuan; Xiong, Qiuchan; Guo, Yuchen; Liang, Yu; Li, Jing; Sheng, Rui; Deng, Peng; Wang, Yuan; Zheng, Rixin; Jiang, Yi-Zhou; Ye, Ling; Chen, Qianming; Zhou, Xuedong; Lin, Shuibin; Yuan, Quan

doi:10.1038/s41467-018-06898-4

Public

Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis

Published in Nature Communications • Nov 8, 2018

Authors:

Yunshu Wu

Liang Xie

Mengyuan Wang

Abstract

Abstract N 6 -methyladenosine (m 6 A) is the most abundant epigenetic modification in eukaryotic mRNAs and is essential for multiple RNA processing events during mammalian development and disease control. Here we show that conditional knockout of the m 6 A methyltransferase Mettl3 in bone marrow mes...

Subject

Mesenchymal stem cell

Conditional gene knockout

Cell biology

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