Inhibiting the NLRP3 Inflammasome With MCC950 Ameliorates Isoflurane-Induced Pyroptosis and Cognitive Impairment in Aged Mice.

Y, Fan; L, Du; Q, Fu; Z, Zhou; J, Zhang; G, Li; J, Wu

doi:10.3389/fncel.2018.00426

Public

Inhibiting the NLRP3 Inflammasome With MCC950 Ameliorates Isoflurane-Induced Pyroptosis and Cognitive Impairment in Aged Mice.

Shared by NobleBlocks on Nov 19, 2018 • 12:00 AM UTC

Authors:

Fan Y

Du L

Fu Q

Abstract

Nod-like receptor protein 3 (NLRP3) inflammasome activation has been implicated in the pathogenesis of general anesthesia (GA)-induced neuroinflammation and cognitive impairment in aged rodents. However, the cellular basis for cognitive impairment is still not fully understood, and effective pharmac...

Subject

Aging

general anesthesia

Cognitive impairment

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