Phenyl-γ-valerolactones and phenylvaleric acids, the main colonic metabolites of flavan-3-ols: synthesis, analysis, bioavailability, and bioactivity

Mena, Pedro; Bresciani, Letizia; Brindani, Nicoletta; A. Ludwig, Iziar; Pereira‐Caro, Gema; Angelino, Donato; Llorach, Rafaël; Calani, Luca; Brighenti, Furio; N. Clifford, Michael; I. R. Gill, Chris; Crozier, Alan; Curti, Claudio; Del Rio, Daniele

doi:10.1039/c8np00062j

Public

Phenyl-γ-valerolactones and phenylvaleric acids, the main colonic metabolites of flavan-3-ols: synthesis, analysis, bioavailability, and bioactivity

Published in Natural Product Reports • Nov 23, 2018

Authors:

Pedro Mena

Letizia Bresciani

Nicoletta Brindani

Abstract

Covering: 1958 to June 2018 Phenyl-γ-valerolactones (PVLs) and their related phenylvaleric acids (PVAs) are the main metabolites of flavan-3-ols, the major class of flavonoids in the human diet. Despite their presumed importance, these gut microbiota-derived compounds have, to date, in terms of biol...

Subject

Bioavailability

Flavan

Chemistry

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