Human stem cell–derived monocytes and microglia‐like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2

Claes, Christel; Van Den Daele, Johanna; Boon, Ruben; Schouteden, Sarah; Colombo, Alessio; Sebastián Monasor, Laura; Fiers, Mark; Ordovás, Laura; Nami, Fatemeharefeh; Bohrmann, Bernd; Tahirović, Sabina; De Strooper, Bart; M. Verfaillie, Catherine

doi:10.1016/j.jalz.2018.09.006

Public

Human stem cell–derived monocytes and microglia‐like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2

Published in Alzheimer s & Dementia • Nov 12, 2018

Authors:

Christel Claes

Johanna Van Den Daele

Ruben Boon

Abstract

Abstract Introduction Murine microglia expressing the Alzheimer's disease–linked TREM2 R47H mutation display variable decrease in phagocytosis, while impaired phagocytosis is reported following loss of TREM2. However, no data exist on TREM2 +/R47H human microglia. Therefore, we created human pluripo...

Subject

TREM2

Microglia

Amyloid (mycology)

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