Human stem cell-derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2.

C, Claes; Den Daele J, Van; R, Boon; S, Schouteden; A, Colombo; LS, Monasor; M, Fiers; L, Ordovás; F, Nami; B, Bohrmann; S, Tahirovic; Strooper B, De; CM, Verfaillie

doi:10.1016/j.jalz.2018.09.006

Public

Human stem cell-derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2.

Shared by NobleBlocks on Nov 12, 2018 • 12:00 AM UTC

Authors:

Claes C

Van Den Daele J

Boon R

Abstract

Introduction Murine microglia expressing the Alzheimer's disease-linked TREM2R47H mutation display variable decrease in phagocytosis, while impaired phagocytosis is reported following loss of TREM2. However, no data exist on TREM2+/R47H human microglia. Therefore, we created human pluripotent stem c...

Subject

Monocytes

Phagocytosis

Alzheimer's disease

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!