Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on <i><scp>TPMT</scp></i> and <i><scp>NUDT</scp>15</i> Genotypes: 2018 Update

V. Relling, Mary; Schwab, Matthias; Whirl‐Carrillo, Michelle; Suarez‐Kurtz, Guilherme; Pui, Ching‐Hon; Stein, Charles; M. Moyer, Ann; E. Evans, William; E. Klein, Teri; Guillermo Antillon‐Klussmann, Federico; E. Caudle, Kelly; Kato, Motohiro; Eng Juh Yeoh, Allen; Schmiegelow, Kjeld; J. Yang, Jun

doi:10.1002/cpt.1304

Public

Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update

Published in Clinical Pharmacology & Therapeutics • Nov 17, 2018

Authors:

Mary V. Relling

Matthias Schwab

Michelle Whirl‐Carrillo

Abstract

Thiopurine methyltransferase (TPMT) activity exhibits a monogenic codominant inheritance and catabolizes thiopurines. TPMT variant alleles are associated with low enzyme activity and pronounced pharmacologic effects of thiopurines. Loss-of-function alleles in the NUDT15 gene are common in Asians and...

Subject

Thiopurine methyltransferase

Dosing

Pharmacogenetics

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