Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on
                    <i>
                      <scp>TPMT</scp>
                    </i>
                    and
                    <i>
                      <scp>NUDT</scp>
                      15
                    </i>
                    Genotypes: 2018 Update

V. Relling, Mary; Schwab, Matthias; Whirl‐Carrillo, Michelle; Suarez‐Kurtz, Guilherme; Pui, Ching‐Hon; M. Stein, Charles; M. Moyer, Ann; E. Evans, William; E. Klein, Teri; Guillermo Antillon‐Klussmann, Federico; E. Caudle, Kelly; Kato, Motohiro; E.J. Yeoh, Allen; Schmiegelow, Kjeld; J. Yang, Jun

doi:10.1002/cpt.1304

Public

Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT 15 Genotypes: 2018 Update

Shared by NobleBlocks on Jan 20, 2019 • 12:00 AM UTC

Authors:

Mary V. Relling

Matthias Schwab

Michelle Whirl‐Carrillo

Abstract

Thiopurine methyltransferase (TPMT) activity exhibits a monogenic codominant inheritance and catabolizes thiopurines. TPMT variant alleles are associated with low enzyme activity and pronounced pharmacologic effects of thiopurines. Loss‐of‐function alleles in the NUDT15 gene are common in Asians and...

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