Knockdown of Long Non-Coding RNA XIST Inhibited Doxorubicin Resistance in Colorectal Cancer by Upregulation of miR-124 and Downregulation of SGK1

Zhu, Jia; Zhang, Rui; Yang, Dongxiang; Li, Jibin; Yan, Xiaofei; Jin, Keer; Li, Wenya; Liu, Xin; Zhao, Jianfeng; Shang, Wen; Yu, Tao

doi:10.1159/000495168

Public

Knockdown of Long Non-Coding RNA XIST Inhibited Doxorubicin Resistance in Colorectal Cancer by Upregulation of miR-124 and Downregulation of SGK1

Published in Cellular Physiology and Biochemistry • Jan 1, 2018

Authors:

Jia Zhu

Rui Zhang

Dongxiang Yang

Abstract

BACKGROUND/AIMS: Doxorubicin (DOX) is a widely used chemotherapeutic agent for colorectal cancer (CRC). However, the acquirement of DOX resistance limits its clinical application for cancer therapy. Mounting evidence has suggested that aberrantly expressed lncRNAs contribute to drug resistance of va...

Subject

XIST

Gene knockdown

Downregulation and upregulation

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