Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair

A. Shook, Brett; R. Wasko, Renee; C. Rivera-Gonzalez, Guillermo; Salazar-Gatzimas, Emilio; López‐Giráldez, Francesc; C. Dash, Biraja; Rojas, Andrés; D. Aultman, Krystal; K. Zwick, Rachel; Lei, Vivian; L. Arbiser, Jack; Miller‐Jensen, Kathryn; A. Clark, Damon; C. Hsia, Henry; Horsley, Valerie

doi:10.1126/science.aar2971

Public

Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair

Published in Science • Nov 22, 2018

Authors:

Brett A. Shook

Renee R. Wasko

Guillermo C. Rivera-Gonzalez

Abstract

During tissue repair, myofibroblasts produce extracellular matrix (ECM) molecules for tissue resilience and strength. Altered ECM deposition can lead to tissue dysfunction and disease. Identification of distinct myofibroblast subsets is necessary to develop treatments for these disorders. We analyze...

Subject

Myofibroblast

Extracellular matrix

Fibrosis

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