Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial

Mehanna, Hisham; Robinson, Max; Hartley, A.; Kong, Anthony; Foran, Bernadette; Fulton‐Lieuw, Tessa; J. Dalby, Matthew; Mistry, Pankaj; Şen, Mehmet; O’Toole, L.; Al Booz, H.; Dyker, K.; Molerón, R.; Whitaker, S.; Brennan, Sinéad; Cook, Audrey; Griffin, Matthew; Aynsley, E.; Rolles, Martin; De Winton, Emma; K. Chan, Andrew; Srinivasan, Devraj; Nixon, Ioanna; Grumett, Joanne; René Leemans, C.; Buter, Jan; Henderson, Julia; J. Harrington, Kevin; C. McConkey, Christopher; Gray, Alastair; Dunn, Janet; Molerón, R.; McArdle, Orla; Dyker, K.; Al Booz, H.; O’Toole, L.; Cook, Audrey; Husband, David; Loo, Vivienne; Soe, Win; Aynsley, E.; Thiagarajan, Sridhar; Jankowska, Petra; Joseph, Mano; Geropantas, K.; Vaidya, Deepali; Griffin, Matthew; Hartley, A.; Vijayan, Rengarajan; Hwang, David; J. Harrington, Kevin; Pettit, Laura; Whitaker, S.; De Winton, Emma; Rolles, Martin; Brennan, Sinéad; Şen, Mehmet; Mendes, R.; Förster, Martin; K. Chan, Andrew; Evans, Mererid; Buter, Jan; Srinivasan, Devraj; Foran, B.; Nankivell, Paul; Bryant, Jennifer; Sharma, Neil; Spruce, Rachel; Brooks, Jill; Batis, Nikos; Roques, Tom; Bidmead, Margaret; Yang, Huiqi; M. Nutting, Christopher; Tyler, Justine; Henderson, Julia; Baines, Helen; Gasnier, Anne; Miles, Elizabeth; H. Clark, Catharine; Evans, Mererid

doi:10.1016/s0140-6736(18)32752-1

Public

Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial

Published in The Lancet • Nov 15, 2018

Authors:

Hisham Mehanna

Max Robinson

A. Hartley

Abstract

BACKGROUND: The incidence of human papillomavirus (HPV)-positive oropharyngeal cancer, a disease affecting younger patients, is rapidly increasing. Cetuximab, an epidermal growth factor receptor inhibitor, has been proposed for treatment de-escalation in this setting to reduce the toxicity of standa...

Subject

Cetuximab

Medicine

Internal medicine

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