Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne

Petridis, Christos; A. Navarini, Alexander; Dand, Nick; Saklatvala, Jake; Baudry, David; Duckworth, Michael; H. Allen, Michael; J. Curtis, Charles; Hyuck Lee, Sang; David Burden, A.; Layton, Alison; Bataille, Veronique; E. Pink, Andrew; Acne Genetic Study Group, The; Alexandroff, Anton; Anstey, Alex; Azad, Jaskiran; Aziz, Omar; Burrows, Nigel; Butt, Aamir; Cartwright, Peter; Chapman, Anna; H. Clayton, Timothy; Cliff, Sandeep; Cutler, Tim; Daly, Brigid; Darvay, Amrit; DeGiovanni, Claudia; Downs, Anthony; Dwyer, Colm; English, John; Ferguson, Adam; Fleming, Colin; Fraser-Andrews, Elizabeth; Goodfield, Mark; E. Grattan, Clive; Hempel, Hartmut; Hood, Sue; Hughes, Bronwyn; Ladoyanni, Evmorfia; Lyon, Calum; Mahmud, Ali; Malik, Moshin; Mallon, Eleanor; Meggitt, Simon; Messenger, Andrew; Moosa, Yaaseen; Munn, Stephanie; Ormerod, Anthony; Rallan, Deepak; Ross, Janet; Salvary, Ingrid; Wachsmuth, Rachel; Wahie, Shyamal; Walton, Shernaz; Walsh, Sarah; Williamson, Diane; Willis, Carolyn; Carlavan, Isabelle; J. Voegel, Johannes; D. Spector, Timothy; C. Trembath, Richard; A. McGrath, John; H. Smith, Catherine; N. Barker, Jonathan; A. Simpson, Michael

doi:10.1038/s41467-018-07459-5

Public

Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne

Shared by NobleBlocks on Dec 12, 2018 • 12:00 AM UTC

Authors:

Christos Petridis

Alexander A. Navarini

Nick Dand

Abstract

Abstract Acne vulgaris is a highly heritable common, chronic inflammatory disease of the skin for which five genetic risk loci have so far been identified. Here, we perform a genome-wide association study of 3823 cases and 16,144 controls followed by meta-analysis with summary statistics from a prev...

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