Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

Mavaddat, Nasim; Michailidou, Kyriaki; Dennis, Joe; Lush, Michael; Fachal, Laura; Lee, Andrew; P. Tyrer, Jonathan; Chen, Ting‐Huei; Wang, Qin; K. Bolla, Manjeet; Yang, Xin; A. Adank, Muriel; U. Ahearn, Thomas; Aittomäki, Kristiina; Allen, Jamie; L. Andrulis, Irene; Anton‐Culver, Hoda; Antonenkova, Natalia; Arndt, Volker; J. Aronson, Kristan; L. Auer, Paul; Auvinen, Päivi; Barrdahl, Myrto; E. Beane Freeman, Laura; W. Beckmann, Matthias; Behrens, Sabine; Benı́tez, Javier; Bermisheva, Marina; Bernstein, Leslie; Blomqvist, Carl; Bogdanova, Natalia; E. Bojesen, Stig; Bonanni, Bernardo; Børresen‐Dale, Anne‐Lise; Brauch, Hiltrud; Bremer, Michael; Brenner, Hermann; R. Brentnall, Adam; W. Brock, Ian; Brooks‐Wilson, Angela; Y. Brucker, Sara; Brüning, Thomas; Burwinkel, Barbara; Campa, Daniele; D. Carter, Brian; E. Castelao, Jose; J. Chanock, Stephen; T. Chlebowski, Rowan; Christiansen, Hans; L. Clarke, Christine; Margriet Collée, J.; Cordina‐Duverger, Emilie; Cornelissen, Sten; J. Couch, Fergus; Cox, Angela; S. Cross, Simon; Czene, Kamila; B. Daly, Mary; Devilee, Peter; Dörk, Thilo; dos‐Santos‐Silva, Isabel; Dumont, Martine; Durcan, Lorraine; Dwek, Miriam; M. Eccles, Diana; B. Ekici, Arif; Heather Eliassen, A.; Ellberg, Carolina; Engel, Christoph; Eriksson, Mikael; Gareth Evans, D.; A. Fasching, Peter; D. Figueroa, Jonine; Fletcher, Olivia; Flyger, Henrik; Försti, Asta; Fritschi, Lin; Gabrielson, Marike; Gago-Domínguez, Manuela; M. Gapstur, Susan; Á. García-Sáenz, José; M. Gaudet, Mia; Georgoulias, V.; G. Giles, Graham; R. Gilyazova, I.; Glendon, Gord; S. Goldberg, Mark; E. Goldgar, David; González‐Neira, Anna; I.G. Alnæs, Grethe; Grip, Mervi; Gronwald, Jacek; Grundy, Anne; Guénel, Pascal; Haeberle, Lothar; Hahnen, Eric; A. Haiman, Christopher; Håkansson, Niclas; Hamann, Ute; E. Hankinson, Susan; F. Harkness, Elaine; N. Hart, Steven; He, Wei; Hein, Alexander; Heyworth, Jane; Hillemanns, Peter; Hollestelle, Antoinette; J. Hooning, Maartje; N. Hoover, Robert; L. Hopper, John; Howell, Anthony; Huang, Guanmengqian; Humphreys, Keith; J. Hunter, David; Jakimovska, Milena; Jakubowska, Anna; Janni, Wolfgang; M. John, Esther; Johnson, Nichola; E. Jones, Michael; Jukkola‐Vuorinen, Arja; Jung, Audrey; Kaaks, Rudolf; Kaczmarek, Katarzyna; Kataja, Vesa; Keeman, Renske; J. Kerin, Michael; К. Хуснутдинова, Э.; I. Kiiski, Johanna; A. Knight, Julia; Ko, Yon‐Dschun; Kosma, Veli‐Matti; Koutros, Stella; N. Kristensen, Vessela; Krüger, Ute; Kühl, Tabea; Lambrechts, Diether; Le Marchand, Loı̈c; Lee, Eunjung; Lejbkowicz, Flavio; Lilyquist, Jenna; Lindblom, Annika; Lindström, Sara; Lissowska, Jolanta; Lo, Wing‐Yee; Loibl, Sibylle; Long, Jirong; Lubiński, Jan; P. Lux, Michael; J. MacInnis, Robert; Maishman, Tom; Makalic, Enes; Maleva Kostovska, Ivana; Mannermaa, Arto; Manoukian, Siranoush; Margolin, Sara; W.M. Martens, John; Elena Martı́nez, Marı́a; Mavroudis, Dimitrios; McLean, Catriona; Meindl, Alfons; Menon, Usha; Middha, Pooja; Miller, Nicola; Moreno, Fernando; Marie Mulligan, Anna; Mulot, Claire; M. Muñoz-Garzón, Víctor; L. Neuhausen, Susan; Nevanlinna, Heli; Neven, Patrick; G. Newman, William; F. Nielsen, Sune; G. Nordestgaard, Børge; D. Norman, Aaron; Offit, Kenneth; E. Olson, Janet; Olsson, Håkan; Orr, Nick; Shane Pankratz, V.; Park‐Simon, Tjoung‐Won; Ignacio Arias Pérez, José; Pérez-Barrios, Clara; Peterlongo, Paolo; Peto, Julian; Pinchev, Mila; Plaseska‐Karanfilska, Dijana; C. Polley, Eric; L. Prentice, Ross; Presneau, Nadège; Prokofyeva, Darya; S. Purrington, Kristen; Pylkäs, Katri; Rack, Brigitte; Radice, Paolo; Rau‐Murthy, Rohini; Rennert, Gad; S. Rennert, Hedy; Rhenius, Valerie; E. Robson, Mark; Romero, Atocha; J. Ruddy, Kathryn; Ruebner, Matthias; Saloustros, Emmanouil; P. Sandler, Dale; J. Sawyer, Elinor; F. Schmidt, Daniel; K. Schmutzler, Rita; Schneeweiß, Andreas; J. Schoemaker, Minouk; R. Schumacher, Fredrick; Schürmann, Peter; Schwentner, Lukas; G. Scott, Christopher; J. Scott, Rodney; Seynaeve, Caroline; Shah, Mitul; E. Sherman, Mark; J. Shrubsole, Martha; Shu, Xiao‐Ou; Slager, Susan; Smeets, Ann; Sohn, Christof; Soucy, Penny; C. Southey, Melissa; J. Spinelli, John; Stegmaier, Christa; Stone, Jennifer; J. Swerdlow, Anthony; M. Tamimi, Rulla; Tapper, William; A. Taylor, Jack; Beth Terry, Mary; Thöne, Kathrin; A.�E.�M. Tollenaar, Rob; Tomlinson, Ian; Truong, Thérèse; Tzardi, Maria; Ulmer, Hans-Ulrich; Untch, Michael; M. Vachon, Celine; M. van Veen, Elke; Vijai, Joseph; R. Weinberg, Clarice; Wendt, Camilla; S. Whittemore, Alice; Wildiers, Hans; C. Willett, Walter; Winqvist, Robert; Wolk, Alicja; R. Yang, Xiaohong; Yannoukakos, Drakoulis; Zhang, Yan; Zheng, Wei; Ziogas, Argyrios; M. Dunning, Alison; J. Thompson, Deborah; Chenevix‐Trench, Georgia; Chang‐Claude, Jenny; K. Schmidt, Marjanka; Hall, Per; L. Milne, Roger; D.P. Pharoah, Paul; C. Antoniou, Antonis; Chatterjee, Nilanjan; Kraft, Peter; García‐Closas, Montserrat; Simard, Jacques; F. Easton, Douglas

doi:10.1016/j.ajhg.2018.11.002

Public

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

Published in The American Journal of Human Genetics • Dec 13, 2018

Authors:

Nasim Mavaddat

Kyriaki Michailidou

Joe Dennis

Abstract

Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, optimized for prediction of estrogen receptor (ER)-specific disease, from the largest available genome-wide associati...

Subject

Breast cancer

Polygenic risk score

Oncology

Research Assistant

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