Genetic Alphabet Expansion Provides Versatile Specificities and Activities of Unnatural-Base DNA Aptamers Targeting Cancer Cells

Futami, Kazunobu; Kimoto, Michiko; Wei Shermane Lim, Yun; Hirao, Ichiro

doi:10.1016/j.omtn.2018.11.011

Public

Genetic Alphabet Expansion Provides Versatile Specificities and Activities of Unnatural-Base DNA Aptamers Targeting Cancer Cells

Published in Molecular Therapy — Nucleic Acids • Nov 29, 2018

Authors:

Kazunobu Futami

Michiko Kimoto

Yun Wei Shermane Lim

Abstract

The potential of genetic alphabet expansion technologies using artificial extra base pairs (unnatural base pairs) has been rapidly expanding and increasing. We present that the hydrophobic unnatural base, 7-(2-thienyl)imidazo[4,5-b]pyridine (Ds), which acts as a fifth letter in a DNA library, provid...

Subject

Aptamer

Cancer cell

Cancer

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!