A human-derived antibody targets misfolded SOD1 and ameliorates motor symptoms in mouse models of amyotrophic lateral sclerosis.

M, Maier; T, Welt; F, Wirth; F, Montrasio; D, Preisig; J, McAfoose; FG, Vieira; L, Kulic; C, Späni; T, Stehle; S, Perrin; M, Weber; C, Hock; RM, Nitsch; J, Grimm

doi:10.1126/scitranslmed.aah3924

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A human-derived antibody targets misfolded SOD1 and ameliorates motor symptoms in mouse models of amyotrophic lateral sclerosis.

Shared by NobleBlocks on Dec 1, 2018 • 12:00 AM UTC

Authors:

Maier M

Welt T

Wirth F

Abstract

Mutations in the gene encoding superoxide dismutase 1 (SOD1) lead to misfolding and aggregation of SOD1 and cause familial amyotrophic lateral sclerosis (FALS). However, the implications of wild-type SOD1 misfolding in sporadic forms of ALS (SALS) remain unclear. By screening human memory B cells fr...

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