Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells

André, Pascale; Denis, Caroline; Soulas, Caroline; Bourbon-Caillet, Clarisse; Lopez, Julie; Arnoux, Thomas; Bléry, Mathieu; Bonnafous, Cécile; Gauthier, Laurent; Morel, Ariane; Rossi, Benjamín; Remark, Romain; Breso, Violette; Bonnet, Elodie; Habif, Guillaume; Guia, Sophie; I. Lalanne, Ana; Hoffmann, Caroline; Lantz, Olivier; Fayette, Jérôme; Boyer-Chammard, Agnès; Zerbib, Robert; Dodion, P.; Ghadially, Hormas; Jure‐Kunkel, Maria; Morel, Yannis; Herbst, Ronald; Narni-Mancinelli, Émilie; B. Cohen, Roger; Vivier, Éric

doi:10.1016/j.cell.2018.10.014

Public

Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells

Published in Cell • Nov 29, 2018

Authors:

Pascale André

Caroline Denis

Caroline Soulas

Abstract

Checkpoint inhibitors have revolutionized cancer treatment. However, only a minority of patients respond to these immunotherapies. Here, we report that blocking the inhibitory NKG2A receptor enhances tumor immunity by promoting both natural killer (NK) and CD8 + T cell effector functions in mice and...

Subject

Biology

Cancer research

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