ROS induces epithelial-mesenchymal transition via the TGF-β1/PI3K/Akt/mTOR pathway in diabetic nephropathy.

Q, Lu; WW, Wang; MZ, Zhang; ZX, Ma; XR, Qiu; M, Shen; XX, Yin

doi:10.3892/etm.2018.7014

Public

ROS induces epithelial-mesenchymal transition via the TGF-β1/PI3K/Akt/mTOR pathway in diabetic nephropathy.

Shared by NobleBlocks on Nov 26, 2018 • 12:00 AM UTC

Authors:

Lu Q

Wang WW

Zhang MZ

Abstract

Oxidative stress has been reported to serve an important role in the development and progression of diabetic nephropathy (DN). Epithelial-mesenchymal transition (EMT) of renal tubular epithelial cells promotes renal fibrosis in DN, while the mechanism of reactive oxygen species (ROS)-mediated EMT is...

Subject

Reactive oxygen species

Phosphoinositide 3 kinase

Diabetes

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