ROS induces epithelial‑mesenchymal transition via the TGF‑β1/PI3K/Akt/mTOR pathway in diabetic nephropathy

Lü, Qian; Wang, Wenwen; Zhang, Mingzhu; Ma, Zhongxuan; Qiu, Xin‐Ran; Shen, Mengli; Yin, Xiaoxing

doi:10.3892/etm.2018.7014

Public

ROS induces epithelial‑mesenchymal transition via the TGF‑β1/PI3K/Akt/mTOR pathway in diabetic nephropathy

Published in Experimental and Therapeutic Medicine • Nov 26, 2018

Authors:

Qian Lü

Wenwen Wang

Mingzhu Zhang

Abstract

Oxidative stress has been reported to serve an important role in the development and progression of diabetic nephropathy (DN). Epithelial‑mesenchymal transition (EMT) of renal tubular epithelial cells promotes renal fibrosis in DN, while the mechanism of reactive oxygen species (ROS)‑mediated EMT is...

Subject

PI3K/AKT/mTOR pathway

Epithelial–mesenchymal transition

Oncogene

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