ROS induces epithelial‑mesenchymal transition via the TGF‑β1/PI3K/Akt/mTOR pathway in diabetic nephropathy

Lü, Qian; Wang, Wenwen; Zhang, Mingzhu; Ma, Zhongxuan; Qiu, Xin‐Ran; Shen, Mengli; Yin, Xiaoxing

doi:10.3892/etm.2018.7014

Public

ROS induces epithelial‑mesenchymal transition via the TGF‑β1/PI3K/Akt/mTOR pathway in diabetic nephropathy

Published in Experimental and Therapeutic Medicine • Nov 26, 2018

Authors:

Qian Lü

Wenwen Wang

Mingzhu Zhang

Abstract

Oxidative stress has been reported to serve an important role in the development and progression of diabetic nephropathy (DN). Epithelial-mesenchymal transition (EMT) of renal tubular epithelial cells promotes renal fibrosis in DN, while the mechanism of reactive oxygen species (ROS)-mediated EMT is...

Subject

PI3K/AKT/mTOR pathway

Epithelial–mesenchymal transition

Oncogene

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