The effects of concomitant immunomodulators on the pharmacokinetics, efficacy and safety of adalimumab in paediatric patients with Crohn’s disease: a post hoc analysis

S. Hyams, Jeffrey; C. Dubinsky, Marla; R. Rosh, Joel; M. Ruemmele, Frank; Eichner, Samantha; Maa, Jen‐Fue; Lazar, Andreas; Alperovich, Gabriela; M. Mostafa, Nael; Robinson, Anne

doi:10.1111/apt.15054

Public

The effects of concomitant immunomodulators on the pharmacokinetics, efficacy and safety of adalimumab in paediatric patients with Crohn’s disease: a post hoc analysis

Published in Alimentary Pharmacology & Therapeutics • Dec 2, 2018

Authors:

Jeffrey S. Hyams

Marla C. Dubinsky

Joel R. Rosh

Abstract

BACKGROUND: In the IMAgINE 1 study, adalimumab induced and maintained remission of moderate-to-severe Crohn's disease in children. AIM: To assess the efficacy, pharmacokinetics, immunogenicity and safety of immunomodulator and adalimumab combination therapy vs adalimumab monotherapy in paediatric pa...

Subject

Adalimumab

Medicine

Internal medicine

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