Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases

Li, Jian-Feng; Dai, Yu-Ting; Lilljebjörn, Henrik; Shen, Shu-Hong; Cui, Bo-Wen; Bai, Ling; Liu, Yuan-Fang; Qian, Mao-Xiang; Kubota, Yasuo; Kiyoi, Hitoshi; Matsumura, Itaru; Miyazaki, Yasushi; Olsson, Linda; Moy Tan, Ah; Ariffin, Hany; Chen, Jing; Takita, Junko; Yasuda, Takahiko; Mano, Hiroyuki; Johansson, Bertil; J. Yang, Jun; Eng-Juh Yeoh, Allen; Hayakawa, Fumihiko; Chen, Zhu; Pui, Ching-Hon; Fioretos, Thoas; Chen, Sai-Juan; Huang, Jin-Yan

doi:10.1073/pnas.1814397115

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Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases

Shared by NobleBlocks on Nov 28, 2018 • 12:00 AM UTC

Authors:

Jian-Feng Li

Yu-Ting Dai

Henrik Lilljebjörn

Abstract

Significance In BCP ALL, molecular classification is used for risk stratification and influences treatment strategies. We reanalyzed the transcriptomic landscape of 1,223 BCP ALLs and identified 14 subgroups based on their transcriptional profiles. Eight of these (G1 to G8) are previously well-known...

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