N-Terminal Liver-Expressed Antimicrobial Peptide 2 (LEAP2) Region Exhibits Inverse Agonist Activity toward the Ghrelin Receptor

M’Kadmi, Céline; Cabral, Agustina; Barrile, Franco; Giribaldi, Julien; Cantel, Sonia; Damian, Marjorie; Mary, Sophie; Denoyelle, Séverine; Dutertre, Sébastien; Péraldi‐Roux, Sylvie; Neasta, Jérémie; Oiry, Catherine; Banères, Jean‐Louis; Marie, Jacky; Perelló, Mario; Fehrentz, Jean‐Alain

doi:10.1021/acs.jmedchem.8b01644

Public

N-Terminal Liver-Expressed Antimicrobial Peptide 2 (LEAP2) Region Exhibits Inverse Agonist Activity toward the Ghrelin Receptor

Published in Journal of Medicinal Chemistry • Dec 13, 2018

Authors:

Céline M’Kadmi

Agustina Cabral

Franco Barrile

Abstract

The ghrelin receptor or growth hormone secretagogue receptor (GHSR) is a G-protein-coupled receptor that controls growth hormone and insulin secretion, food intake, and reward-seeking behaviors. Liver-expressed antimicrobial peptide 2 (LEAP2) was recently described as an endogenous antagonist of GHS...

Subject

Ghrelin

Growth hormone secretagogue receptor

Inverse agonist

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