MiR-1292 Targets FZD4 to Regulate Senescence and Osteogenic Differentiation of Stem Cells in TE/SJ/Mesenchymal Tissue System via the Wnt/β-catenin Pathway

Fan, Junfen; An, Xingyan; Yang, Yanlei; Xu, Haoying; Fan, Linyuan; Deng, Luchan; Li, Tao; Weng, Xisheng; Zhang, Jianmin; Chunhua Zhao, Robert

doi:10.14336/ad.2018.1110

Public

MiR-1292 Targets FZD4 to Regulate Senescence and Osteogenic Differentiation of Stem Cells in TE/SJ/Mesenchymal Tissue System via the Wnt/β-catenin Pathway

Published in Aging and Disease • Jan 1, 2018

Authors:

Junfen Fan

Xingyan An

Yanlei Yang

Abstract

With the expansion of the elderly population, age-related osteoporosis and the resulting bone loss have become a significant health and socioeconomic issue. In Triple Energizer (TE)/San Jiao (SJ)/mesenchymal tissue system, mesenchymal stem cell (MSC) senescence, and impaired osteogenesis are thought...

Subject

Mesenchymal stem cell

Senescence

Wnt signaling pathway

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