Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis

Zeng, Zhicheng; Li, Yuling; Pan, Yangjian; Lan, Xiao-Liang; Song, Fuyao; Sun, Jingbo; Zhou, Kun; Liu, Xiaolong; Ren, Xiaoli; Wang, Feifei; Hu, Jinlong; Zhu, Xiaohui; Yang, Wei; Liao, Wenting; Li, Guoxin; Ding, Yanqing; Li, Liang

doi:10.1038/s41467-018-07810-w

Public

Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis

Published in Nature Communications • Dec 13, 2018

Authors:

Zhicheng Zeng

Yuling Li

Yangjian Pan

Abstract

Cancer-derived exosomes are considered a major driver of cancer-induced pre-metastatic niche formation at foreign sites, but the mechanisms remain unclear. Here, we show that miR-25-3p, a metastasis-promoting miRNA of colorectal cancer (CRC), can be transferred from CRC cells to endothelial cells vi...

Subject

Microvesicles

Metastasis

Angiogenesis

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