Transcriptome and epigenome landscape of human cortical development modeled in organoids

Amiri, Anahita; Coppola, Gianfilippo; Scuderi, Soraya; Wu, Feinan; Roychowdhury, Tanmoy; Liu, Fuchen; Pochareddy, Sirisha; Shin, Yurae; Safi, Alexias; Song, Lingyun; Zhu, Ying; M. M. Sousa, André; Gerstein, Mark; E. Crawford, Gregory; Šestan, Nenad; Abyzov, Alexej; M. Vaccarino, Flora; Akbarian, Schahram; An, Joon‐Yong; Armoskus, Christoper; E. Ashley‐Koch, Allison; G. Beach, Thomas; Belmont, Judson; Bendl, Jaroslav; Borrman, Tyler; Brown, Leanne; Brown, Miguel; Brown, Mimi; M. Brunetti, Tonya; Bryois, Julien; E. Burke, Emily; Camarena, Adrian; C. Carlyle, Becky; Chae, Yooree; W. Charney, Alexander; Chen, Chao; Cheng, Lijun; Cherskov, Adriana; Choi, Jinmyung; Clarke, Declan; Collado‐Torres, Leonardo; Dai, Rujia; de la Torre-Ubieta, Luis; M. Del Valle, Diane; Devillers, Olivia; Dracheva, Stella; S. Emani, Prashant; V. Evgrafov, Oleg; Farnham, Peggy; Fitzgerald, Dominic; Flatow, Elie; Francoeur, Nancy; F. Fullard, John; J. Gandal, Michael; Gao, Tianliuyun; E. Garrett, Melanie; H. Geschwind, Daniel; Giase, Gina; Girdhar, Kiran; Giusti‐Rodríguez, Paola; S. Goes, Fernando; Goodman, Thomas; Grennan, Kay; Gu, Mengting; Gürsoy, Gamze; Hadjimichael, Evi; Hahn, Chang-Gyu; Haroutunian, Vahram; E. Hauberg, Mads; E. Hoffman, Gabriel; Huey, Jack; M. Hyde, Thomas; A. Ivanov, Nikolay; Jacobov, Rivka; E. Jaffe, Andrew; Jiang, Yan; Jiang, Yi; D. Johnson, Graham; Kassim, Bibi; Kefi, Amira; Kim, Yunjung; R. Kitchen, Robert; E. Kleiman, Joel; A. Knowles, James; Kozlenkov, Alexey; Li, Mingfeng; Li, Zhen; K. Lipska, Barbara; Liu, Chunyu; Liu, Shuang; M. Mangravite, Lara; Mariani, Jessica; Mattei, Eugenio; J. Miller, Daniel; Russell Moore, J.; C. Nairn, Angus; C. P. Navarro, Fábio; Park, Royce; A. Peters, Mette; Pinto, Dalila; Pochareddy, Sirisha; Polioudakis, Damon; Pratt, Henry; J. Price, Amanda; Purcaro, Michael; Ray, Mohana; E. Reddy, Timothy; K. Rhie, Suhn; Roussos, Panos; Sanders, Stephan; Santpere, Gabriel; Schreiner, Shannon; Sheppard, Brooke; Shi, Xu; W. Shieh, Annie; Heon Shin, Joo; Škarica, Mario; Song, Lingyun; M. M. Sousa, André; N. Spitsyna, Valeria; W. State, Matthew; F. Sullivan, Patrick; Swarup, Vivek; Szatkiewicz, Jin; Szekely, Anna; Tao, Ran; van Bakel, Harm; Wang, Yongjun; Wang, Daifeng; Warrell, Jonathan; J. Webster, Maree; M. Weissman, Sherman; Weng, Zhiping; M. Werling, Donna; P. White, Kevin; A. Willsey, Jeremy; Wiseman, Jennifer; Witt, Heather; Won, Hyejung; A. Wray, Gregory; Xia, Yan; Xu, Min; Yang, Yucheng; Yang, Mo; P. Zandi, Peter; Zhang, Jing; Zharovsky, Elizabeth

doi:10.1126/science.aat6720

Public

Transcriptome and epigenome landscape of human cortical development modeled in organoids

Published in Science • Dec 13, 2018

Authors:

Anahita Amiri

Gianfilippo Coppola

Soraya Scuderi

Abstract

INTRODUCTION The human cerebral cortex has undergone an extraordinary increase in size and complexity during mammalian evolution. Cortical cell lineages are specified in the embryo, and genetic and epidemiological evidence implicates early cortical development in the etiology of neuropsychiatric dis...

Subject

Enhancer

Epigenome

Organoid

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