Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

J. Gandal, Michael; Zhang, Pan; Hadjimichael, Evi; L. Walker, Rebecca; Chen, Chao; Liu, Shuang; Won, Hyejung; van Bakel, Harm; Varghese, Merina; Wang, Yongjun; W. Shieh, Annie; R. Haney, Jillian; Parhami, Sepideh; Belmont, Judson; Kim, Minsoo; Morán Losada, Patricia; Khan, Zenab; Mleczko, Justyna; Xia, Yan; Dai, Rujia; Wang, Daifeng; Yang, Yucheng; Xu, Min; Fish, Kenneth; R. Hof, Patrick; Warrell, Jonathan; Fitzgerald, Dominic; P. White, Kevin; E. Jaffe, Andrew; A. Peters, Mette; Gerstein, Mark; Liu, Chunyu; M. Iakoucheva, Lilia; Pinto, Dalila; H. Geschwind, Daniel; E. Ashley‐Koch, Allison; E. Crawford, Gregory; E. Garrett, Melanie; Song, Lingyun; Safi, Alexias; D. Johnson, Graham; A. Wray, Gregory; E. Reddy, Timothy; S. Goes, Fernando; P. Zandi, Peter; Bryois, Julien; E. Jaffe, Andrew; J. Price, Amanda; A. Ivanov, Nikolay; Collado‐Torres, Leonardo; M. Hyde, Thomas; E. Burke, Emily; E. Kleiman, Joel; Tao, Ran; Heon Shin, Joo; Akbarian, Schahram; Girdhar, Kiran; Jiang, Yan; Kundaković, Marija; Brown, Leanne; Kassim, Bibi; Park, Royce; Wiseman, Jennifer; Zharovsky, Elizabeth; Jacobov, Rivka; Devillers, Olivia; Flatow, Elie; E. Hoffman, Gabriel; K. Lipska, Barbara; A. Lewis, David; Haroutunian, Vahram; Hahn, Chang-Gyu; W. Charney, Alexander; Dracheva, Stella; Kozlenkov, Alexey; Belmont, Judson; M. Del Valle, Diane; Francoeur, Nancy; Hadjimichael, Evi; Pinto, Dalila; van Bakel, Harm; Roussos, Panos; F. Fullard, John; Bendl, Jaroslav; E. Hauberg, Mads; M. Mangravite, Lara; A. Peters, Mette; Chae, Yooree; Peng, Junmin; Niu, Mingming; Wang, Xusheng; J. Webster, Maree; G. Beach, Thomas; Chen, Chao; Jiang, Yi; Dai, Rujia; W. Shieh, Annie; Liu, Chunyu; Grennan, Kay; Xia, Yan; Vadukapuram, Ramu; Wang, Yongjun; Fitzgerald, Dominic; Cheng, Lijun; Brown, Miguel; Brown, Mimi; M. Brunetti, Tonya; Goodman, Thomas; Alsayed, Majd; J. Gandal, Michael; H. Geschwind, Daniel; Won, Hyejung; Polioudakis, Damon; Wamsley, Brie; Yin, Jiani; Hadžić, Tarik; de la Torre-Ubieta, Luis; Swarup, Vivek; Sanders, Stephan; W. State, Matthew; M. Werling, Donna; An, Joon‐Yong; Sheppard, Brooke; Jeremy Willsey, A.; P. White, Kevin; Ray, Mohana; Giase, Gina; Kefi, Amira; Mattei, Eugenio; Purcaro, Michael; Weng, Zhiping; E. Moore, Jill; Pratt, Henry; Huey, Jack; Borrman, Tyler; F. Sullivan, Patrick; Giusti‐Rodríguez, Paola; Kim, Yunjung; Sullivan, Patrick; Szatkiewicz, Jin; K. Rhie, Suhn; Armoskus, Christoper; Camarena, Adrian; Farnham, Peggy; N. Spitsyna, Valeria; Witt, Heather; Schreiner, Shannon; V. Evgrafov, Oleg; A. Knowles, James; Gerstein, Mark; Liu, Shuang; Wang, Daifeng; C. P. Navarro, Fábio; Warrell, Jonathan; Clarke, Declan; S. Emani, Prashant; Gu, Mengting; Shi, Xu; Xu, Min; Yang, Yucheng; R. Kitchen, Robert; Gürsoy, Gamze; Zhang, Jing; C. Carlyle, Becky; C. Nairn, Angus; Li, Mingfeng; Pochareddy, Sirisha; Šestan, Nenad; Škarica, Mario; Li, Zhen; M. M. Sousa, André; Santpere, Gabriel; Choi, Jinmyung; Zhu, Ying; Gao, Tianliuyun; J. Miller, Daniel; Cherskov, Adriana; Yang, Mo; Amiri, Anahita; Coppola, Gianfilippo; Mariani, Jessica; Scuderi, Soraya; Szekely, Anna; M. Vaccarino, Flora; Wu, Feinan; M. Weissman, Sherman; Roychowdhury, Tanmoy; Abyzov, Alexej

doi:10.1126/science.aat8127

Public

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

Published in Science • Dec 13, 2018

Authors:

Michael J. Gandal

Pan Zhang

Evi Hadjimichael

Abstract

INTRODUCTION Our understanding of the pathophysiology of psychiatric disorders, including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD), lags behind other fields of medicine. The diagnosis and study of these disorders currently depend on behavioral, symptomatic chara...

Subject

Transcriptome

Biology

Schizophrenia (object-oriented programming)

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