Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies

Abou‐Khalil, Bassel; Auce, Pauls; Avberšek, Andreja; Bahlo, Melanie; J. Balding, David; Bast, Thomas; Baum, Larry; J. Becker, Albert; Becker, Felicitas; Berghuis, Bianca; F. Berkovic, Samuel; Boysen, Katja; P. Bradfield, Jonathan; C. Brody, Lawrence; J. Buono, Russell; Campbell, Ellen; D. Cascino, Gregory; B. Catarino, Claudia; L. Cavalleri, Gianpiero; S. Cherny, Stacey; Chinthapalli, Krishna; J. Coffey, Alison; Compston, Alastair; Coppola, Antonietta; Cossette, Patrick; Craig, John; de Haan, Gerrit‐Jan; De Jonghe, Peter; G. F. de Kovel, Carolien; Delanty, Norman; Depondt, Chantal; Devinsky, Orrin; Dlugos, Dennis; P. Doherty, Colin; E. Elger, Christian; G. Eriksson, Johan; N. Ferraro, Thomas; Feucht, Martha; Francis, Ben; Franke, André; A. French, Jacqueline; Freytag, Saskia; Gaus, Verena; B. Geller, Eric; Gieger, Christian; A. Glauser, Tracy; Glynn, Simon; B. Goldstein, David; Gui, Hongsheng; Guo, Youling; F. Haas, Kevin; Håkonarson, Håkon; Hallmann, Kerstin; R. Haut, Sheryl; L. Heinzen, Erin; Helbig, Ingo; Hengsbach, Christian; Hjalgrim, Helle; Iacomino, Michele; Ingason, Andrés; Jamnadas-Khoda, Jennifer; R. Johnson, Michael; Kälviäinen, Reetta; Kantanen, Anne-Mari; Kasperavičiūtė, Dalia; Kasteleijn‐Nolst Trenité, Dorothée; E. Kirsch, Heidi; C. Knowlton, Robert; P.C. Koeleman, Bobby; Krause, Roland; Krenn, Martin; S. Kunz, Wolfram; Kuzniecky, Ruben; Kwan, Patrick; Lal, Dennis; Lau, YL; Lehesjoki, Anna‐Elina; Lerche, Holger; Leu, Costin; Lieb, Wolfgang; Lindhout, Dick; Lo, Warren; Lopes‐Cendes, Íscia; H. Lowenstein, Daniel; Malovini, Alberto; G Marson, Anthony; Mayer, Thomas; McCormack, Mark; L. Mills, James; Mirza, Nasir; Moerzinger, Martina; S. Møller, Rikke; M. Molloy, Anne; Muhle, Hiltrud; R. Newton, Mark; Ng, Ping-Wing; M. Nöthen, Markus; Nürnberg, Peter; J. O’Brien, Terence; Oliver, Karen; Palotie, Aarno; Pangilinan, Faith; Peter, Sarah; Petrovski, Slavé; Poduri, Annapurna; Privitera, Michael; A. Radtke, Rodney; Rau, Sarah; S. Reif, Philipp; M. Reinthaler, Eva; Rosenow, Felix; W. Sander, Josemir; Sander, Thomas; Scattergood, Theresa; C. Schachter, Steven; J. Schankin, Christoph; E. Scheffer, Ingrid; Schmitz, Bettina; Schoch, Susanne; C. Sham, Pak; J. Shih, Jerry; J. Sills, Graeme; M. Sisodiya, Sanjay; Slattery, Lisa; C.W. Smith, Alexander; F. Smith, David; C. Smith, Michael; E M Smith, Phil; C. M. Sonsma, Anja; Speed, Doug; R. Sperling, Michael; J. Steinhoff, Bernhard; Stephani, Ulrich; Stevelink, Remi; Strauch, Konstantin; Striano, Pasquale; Stroink, Hans; Surges, Rainer; Meng Tan, K.; Lin Thio, Liu; Neil Thomas, G.; Todaro, Marian; Tozzi, Rossana; Stella Vari, Maria; P.G. Vining, Eileen; Visscher, Frank; von Spiczak, Sarah; Walley, Nicole; Weber, Yvonne; Wei, Zhi; Weisenberg, Judith; D. Whelan, Christopher; Widdess‐Walsh, Peter; Wolff, Markus; Wolking, Stefan; Yang, Wanling; Zara, Federico; Zimprich, Fritz

doi:10.1038/s41467-018-07524-z

Public

Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies

Published in Nature Communications • Dec 4, 2018

Authors:

Bassel Abou‐Khalil

Pauls Auce

Andreja Avberšek

Abstract

The epilepsies affect around 65 million people worldwide and have a substantial missing heritability component. We report a genome-wide mega-analysis involving 15,212 individuals with epilepsy and 29,677 controls, which reveals 16 genome-wide significant loci, of which 11 are novel. Using various pr...

Subject

Epilepsy

Biology

Epigenetics

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