Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain

Zhu, Shouan; Zhu, Jianxi; Zhen, Gehua; Hu, Yihe; An, Senbo; Li, Yusheng; Qin, Zheng; Chen, Zhiyong; Yang, Ya; Wan, Mei; L. Skolasky, Richard; Cao, Yong; Wu, Tianding; Gao, Bo; Yang, Mi; Gao, Manman; Kuliwaba, J.S.; Ni, Shuangfei; Wang, Lei; Wu, Chuanlong; M. Findlay, David; K. Eltzschig, Holger; Ouyang, Hong; L. Crane, Janet; Zhou, Feng‐Quan; Guan, Yun; Dong, Xinzhong; Cao, Xu

doi:10.1172/jci121561

Public

Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain

Published in Journal of Clinical Investigation • Dec 11, 2018

Authors:

Shouan Zhu

Jianxi Zhu

Gehua Zhen

Abstract

Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms remain unclear. Here, we investigated an unprecedented role of osteoclast-initiated subchondral bone remodeling in sensory innervation for OA pain. We show that osteoclasts secrete netrin-1 to induce sensory nerv...

Subject

Osteoclast

RANKL

Osteoarthritis

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