Underdiagnosis of Hereditary Breast Cancer: Are Genetic Testing Guidelines a Tool or an Obstacle?

D. Beitsch, Peter; W. Whitworth, Pat; S. Hughes, Kevin; Patel, Rakesh; P. Rosen, Barry; Compagnoni, Gia; L. Baron, Paul; M. Simmons, Rache; Smith, Linda; Grady, Ian; Kinney, Michael; Coomer, C; Ruth Michio Barbosa, Karen; R. Holmes, Dennis; Brown, Eric; Gold, Linsey; Clark, Patricia; B. Riley, Lee; Lyons, Samuel; Ruiz, Antonio; Kahn, Sadia; Macdonald, Heather; D. Curcio, Lisa; Kay Hardwick, Mary; Yang, Shan; D. Esplin, Edward; L. Nussbaum, Robert

doi:10.1200/jco.18.01631

Public

Underdiagnosis of Hereditary Breast Cancer: Are Genetic Testing Guidelines a Tool or an Obstacle?

Published in Journal of Clinical Oncology • Dec 7, 2018

Authors:

Peter D. Beitsch

Pat W. Whitworth

Kevin S. Hughes

Abstract

PURPOSE: An estimated 10% of breast and ovarian cancers result from hereditary causes. Current testing guidelines for germ line susceptibility genes in patients with breast carcinoma were developed to identify carriers of BRCA1/ 2 variants and have evolved in the panel-testing era. We evaluated the ...

Subject

Medicine

Breast cancer

Genetic testing

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