Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

E. Tron, Adriana; A. Belmonte, Matthew; Adam, Ammar; Aquila, Brian; Boise, Lawrence; Chiarparin, Elisabetta; Cidado, Justin; J. Embrey, Kevin; T. Gangl, Eric; D. Gibbons, Francis; P. Gregory, Gareth; Hargreaves, David; Adam Hendricks, J.; W. Johannes, Jeffrey; W. Johnstone, Ricky; L. Kazmirski, Steven; G. Kettle, Jason; L. Lamb, Michelle; M. Matulis, Shannon; K. Nooka, Ajay; J. Packer, Martin; Peng, Bo; B. Rawlins, Philip; Robbins, Daniel; G. Schuller, Alwin; Su, Nancy; Yang, Wenzhan; Ye, Qing; Zheng, Xiaolan; Paul Secrist, J.; Clark, Edwin; M. Wilson, David; E. Fawell, Stephen; W. Hird, Alexander

doi:10.1038/s41467-018-07551-w

Public

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

Published in Nature Communications • Dec 11, 2018

Authors:

Adriana E. Tron

Matthew A. Belmonte

Ammar Adam

Abstract

Mcl-1 is a member of the Bcl-2 family of proteins that promotes cell survival by preventing induction of apoptosis in many cancers. High expression of Mcl-1 causes tumorigenesis and resistance to anticancer therapies highlighting the potential of Mcl-1 inhibitors as anticancer drugs. Here, we descri...

Subject

Venetoclax

Myeloid leukemia

Multiple myeloma

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