CADD: predicting the deleteriousness of variants throughout the human genome

Rentzsch, Philipp; Witten, Daniela; M. Cooper, Gregory; Shendure, Jay; Kircher, Martin

doi:10.1093/nar/gky1016

Public

CADD: predicting the deleteriousness of variants throughout the human genome

Published in Nucleic Acids Research • Oct 11, 2018

Authors:

Philipp Rentzsch

Daniela Witten

Gregory M. Cooper

Abstract

Combined Annotation-Dependent Depletion (CADD) is a widely used measure of variant deleteriousness that can effectively prioritize causal variants in genetic analyses, particularly highly penetrant contributors to severe Mendelian disorders. CADD is an integrative annotation built from more than 60 ...

Subject

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Biology

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