<i>EGFR</i> -Mutant Adenocarcinomas That Transform to Small-Cell Lung Cancer and Other Neuroendocrine Carcinomas: Clinical Outcomes

Marcoux, Nicolas; Gettinger, Scott; M. O’Kane, Grainne; C. Arbour, Kathryn; W. Neal, Joel; Husain, Hatim; L. Evans, Tracey; R. Brahmer, Julie; Muzikansky, Alona; Bonomi, Philip; Del Prete, Salvatore; Wurtz, Anna; F. Farago, Anna; Dias‐Santagata, Dora; Mino–Kenudson, Mari; L. Reckamp, Karen; A. Yu, Helena; A. Wakelee, Heather; A. Shepherd, Frances; Piotrowska, Zofia; V. Sequist, Lecia

doi:10.1200/jco.18.01585

Public

EGFR -Mutant Adenocarcinomas That Transform to Small-Cell Lung Cancer and Other Neuroendocrine Carcinomas: Clinical Outcomes

Published in Journal of Clinical Oncology • Dec 14, 2018

Authors:

Nicolas Marcoux

Scott Gettinger

Grainne M. O’Kane

Abstract

PURPOSE: Approximately 3% to 10% of EGFR (epidermal growth factor receptor) -mutant non-small cell lung cancers (NSCLCs) undergo transformation to small-cell lung cancer (SCLC), but their clinical course is poorly characterized. METHODS: We retrospectively identified patients with EGFR-mutant SCLC a...

Subject

Medicine

T790M

Internal medicine

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