Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration

Upadhya, Dinesh; Hattiangady, Bharathi; Wagner de Castro, Olagide; Shuai, Bing; Kodali, Maheedhar; Attaluri, Sahithi; Bates, Adrian; Dong, Yi; Zhang, Su-Chun; J. Prockop, Darwin; K. Shetty, Ashok

doi:10.1073/pnas.1814185115

Public

Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration

Published in Proceedings of the National Academy of Sciences • Dec 17, 2018

Authors:

Dinesh Upadhya

Bharathi Hattiangady

Olagide Wagner de Castro

Abstract

Medial ganglionic eminence (MGE)-like interneuron precursors derived from human induced pluripotent stem cells (hiPSCs) are ideal for developing patient-specific cell therapy in temporal lobe epilepsy (TLE). However, their efficacy for alleviating spontaneous recurrent seizures (SRS) or cognitive, m...

Subject

Status epilepticus

Neuroscience

Induced pluripotent stem cell

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