ECT2/PSMD14/PTTG1 axis promotes the proliferation of glioma through stabilizing E2F1

Zhi, Tongle; Jiang, Kuan; Xu, Xiupeng; Yu, Tianfu; Zhou, Fengqi; Wang, Yingyi; Liu, Ning; Zhang, Junxia

doi:10.1093/neuonc/noy207

Public

ECT2/PSMD14/PTTG1 axis promotes the proliferation of glioma through stabilizing E2F1

Published in Neuro-Oncology • Dec 22, 2018

Authors:

Tongle Zhi

Kuan Jiang

Xiupeng Xu

Abstract

BACKGROUND: Epithelial cell transformation sequence 2 (ECT2) is upregulated in glioma and promotes glioma cell proliferation. A preliminary experiment showed a positive correlation between ECT2 and pituitary tumor-transforming gene 1 (PTTG1). The aim of this study was to explore how ECT2 affects PTT...

Subject

Glioma

Downregulation and upregulation

Cell growth

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