GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

Patel, Satish; Álvarez-Guaita, Anna; Melvin, Audrey; Rimmington, Debra; Dattilo, Alessia; L. Miedzybrodzka, Emily; Cimino, Irène; Maurin, Anne‐Catherine; Roberts, Geoffrey; L. Meek, Claire; Virtue, Sam; M. Sparks, Lauren; A. Parsons, Stephanie; M. Redman, Leanne; A. Bray, George; P. Liou, Alice; Woods, Rachel; Parry, Siôn; Bendix Jeppesen, Per; J. Kolnes, Anders; P. Harding, Heather; Ron, David; Vidal‐Puig, Antonio; Reimann, Frank; M. Gribble, Fiona; J. Hulston, Carl; Sadaf Farooqi, I.; Fafournoux, Pierre; R. Smith, Steven; Jensen, Jorgen; M. Breen, Danna; Wu, Zhidan; B. Zhang, Bei; P. Coll, Anthony; B. Savage, David; O’Rahilly, Stephen

doi:10.1016/j.cmet.2018.12.016

Public

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

Published in Cell Metabolism • Jan 10, 2019

Authors:

Satish Patel

Anna Álvarez-Guaita

Audrey Melvin

Abstract

GDF15 is an established biomarker of cellular stress. The fact that it signals via a specific hindbrain receptor, GFRAL, and that mice lacking GDF15 manifest diet-induced obesity suggest that GDF15 may play a physiological role in energy balance. We performed experiments in humans, mice, and cells t...

Subject

GDF15

Leptin

Endocrinology

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