Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer

Zadra, Giorgia; F. Ribeiro, Caroline; Chetta, Paolo; Ho, Yeung; Cacciatore, Stefano; Gao, Xueliang; Syamala, Sudeepa; Bango, Clyde; Photopoulos, Cornelia; Huang, Ying; Tyekucheva, Svitlana; C. Bastos, Debora; Tchaicha, Jeremy; Lawney, Brian; Uo, Takuma; D’Anello, Laura; Csibi, Alfredo; Kalekar, Radha; Larimer, Benjamin; Ellis, Leigh; M. Butler, Lisa; Morrissey, Colm; McGovern, Karen; J. Palombella, Vito; L. Kutok, Jeffery; Mahmood, Umar; Bosari, Silvano; Adams, Julian; Peluso, Stephane; M. Dehm, Scott; R. Plymate, Stephen; Loda, Massimo

doi:10.1073/pnas.1808834116

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Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer

Shared by NobleBlocks on Dec 21, 2018 • 12:00 AM UTC

Authors:

Giorgia Zadra

Caroline F. Ribeiro

Paolo Chetta

Abstract

A hallmark of prostate cancer progression is dysregulation of lipid metabolism via overexpression of fatty acid synthase (FASN), a key enzyme in de novo fatty acid synthesis. Metastatic castration-resistant prostate cancer (mCRPC) develops resistance to inhibitors of androgen receptor (AR) signaling...

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