Orexin/hypocretin receptor modulation of anxiolytic and antidepressive responses during social stress and decision-making: Potential for therapy

H. Summers, Cliff; D. W. Yaeger, Jazmine; D. Staton, Clarissa; H. Arendt, David; R. Summers, Tangi

doi:10.1016/j.brainres.2018.12.036

Public

Orexin/hypocretin receptor modulation of anxiolytic and antidepressive responses during social stress and decision-making: Potential for therapy

Published in Brain Research • Dec 24, 2018

Authors:

Cliff H. Summers

Jazmine D. W. Yaeger

Clarissa D. Staton

Abstract

Hypothalmic orexin/hypocretin (Orx) neurons in the lateral and dorsomedial perifornical region (LH-DMH/PeF) innervate broadly throughout the brain, and receive similar inputs. This wide distribution, as well as two Orx peptides (OrxA and OrxB) and two Orx receptors (Orx1 and Orx2) allow for function...

Subject

Orexin

Anxiolytic

Anxiogenic

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