Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids

Wang, Kai; Liao, Mingfang; Zhou, Nan; Li, Bao; Ma, Ke; Zheng, Zhongyong; Wang, Yujing; Liu, Chang; Wang, Wenzhao; Wang, Jun; Liu, Shuang‐Jiang; Liu, Hongwei

doi:10.1016/j.celrep.2018.12.028

Public

Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids

Published in Cell Reports • Jan 1, 2019

Authors:

Kai Wang

Mingfang Liao

Nan Zhou

Abstract

We demonstrated the metabolic benefits of Parabacteroides distasonis (PD) on decreasing weight gain, hyperglycemia, and hepatic steatosis in ob/ob and high-fat diet (HFD)-fed mice. Treatment with live P. distasonis (LPD) dramatically altered the bile acid profile with elevated lithocholic acid (LCA)...

Subject

Obesity

Chemistry

Biochemistry

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