Structural Insights into Phylloquinone (Vitamin K1), Menaquinone (MK4, MK7), and Menadione (Vitamin K3) Binding to VKORC1

Chatron, Nolan; Hammed, Abdessalem; Benoît, Etienne; Lattard, Virginie

doi:10.3390/nu11010067

Public

Structural Insights into Phylloquinone (Vitamin K1), Menaquinone (MK4, MK7), and Menadione (Vitamin K3) Binding to VKORC1

Published in Nutrients • Jan 1, 2019

Authors:

Nolan Chatron

Abdessalem Hammed

Etienne Benoît

Abstract

Vitamin K family molecules-phylloquinone (K1), menaquinone (K2), and menadione (K3)-act as γ-glutamyl carboxylase (GGCX)-exclusive cofactors in their hydroquinone state, activating proteins of main importance for blood coagulation in the liver and for arterial calcification prevention and energy met...

Subject

Menadione

Vitamin K2

Vitamin

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