Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

Haberman, Yael; Karns, Rebekah; J. Dexheimer, Phillip; Schirmer, Melanie; Somekh, Judith; Jurickova, Ingrid; Braun, Tzipi; Novak, Elizabeth; E. Bauman, Laura; H. Collins, Margaret; Mo, Angela; J. Rosen, Michael; Bonkowski, Erin; Gotman, Nathan; Marquis, Alison; Nistel, Mason; A. Rufo, Paul; S. Baker, Susan; G. Sauer, Cary; Markowitz, James; D. Pfefferkorn, Marian; R. Rosh, Joel; M. Boyle, Brendan; Mack, David; N. Baldassano, Robert; Shah, Sapana; S. LeLeiko, Neal; B. Heyman, Melvin; M. Grifiths, Anne; Patel, Ashish; D. Noe, Joshua; J. Aronow, Bruce; Kugathasan, Subra; D. Walters, Thomas; Gibson, Greg; Thomas, Sonia; P. Mollen, Kevin; S. Shen-Orr, Shai; Huttenhower, Curtis; J. Xavier, Ramnik; S. Hyams, Jeffrey; A. Denson, Lee

doi:10.1038/s41467-018-07841-3

Public

Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

Published in Nature Communications • Dec 28, 2018

Authors:

Yael Haberman

Rebekah Karns

Phillip J. Dexheimer

Abstract

Abstract Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are not well understood. Here, we use RNAseq to define pre-treatment rectal gene expression, and fecal microbiota profiles, in 206 pediatric UC patients receiving standardised therapy. We validate...

Subject

Ulcerative colitis

Transcriptome

Inflammatory bowel disease

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