p53 reactivation with induction of massive apoptosis-1 (PRIMA-1) inhibits amyloid aggregation of mutant p53 in cancer cells

P. Rangel, Luciana; D. S. Ferretti, Giulia; L. Costa, Caroline; M.M.V. Andrade, Sarah; S. Carvalho, Renato; C. Ferraz da Costa, Danielly; L. Silva, Jerson

doi:10.1074/jbc.ra118.004671

Public

p53 reactivation with induction of massive apoptosis-1 (PRIMA-1) inhibits amyloid aggregation of mutant p53 in cancer cells

Published in Journal of Biological Chemistry • Jan 3, 2019

Authors:

Luciana P. Rangel

Giulia D. S. Ferretti

Caroline L. Costa

Abstract

p53 mutants can form amyloid-like structures that accumulate in cells. p53 reactivation with induction of massive apoptosis-1 (PRIMA-1) and its primary active metabolite, 2-methylene-3-quinuclidinone (MQ), can restore unfolded p53 mutants to a native conformation that induces apoptosis and activates...

Subject

Mutant

Apoptosis

Amyloid (mycology)

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