Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts

Zhou, Yuan; Ren, Haozhen; Dai, Bo; Li, Jun; Shang, Longcheng; Huang, Jianfei; Shi, Xiaolei

doi:10.1186/s13046-018-0965-2

Public

Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts

Published in Journal of Experimental & Clinical Cancer Research • Dec 27, 2018

Authors:

Yuan Zhou

Haozhen Ren

Bo Dai

Abstract

BACKGROUND: Hepatocellular carcinoma (HCC) remains a global challenge due to its high morbidity and mortality rates as well as poor response to treatment. The communication between tumor-derived elements and stroma plays a critical role in facilitating cancer progression of HCC. Exosomes are small e...

Subject

Hepatocellular carcinoma

Hepatic stellate cell

microRNA

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