Changes in Synaptic Proteins Precede Neurodegeneration Markers in Preclinical Alzheimer's Disease Cerebrospinal Fluid

Lleó, Alberto; Núñez‐Llaves, Raúl; Alcolea, Daniel; Chiva, Cristina; Balateu-Paños, Daniel; Colom‐Cadena, Martí; Gomez‐Giro, Gemma; Muñoz, Laia; Querol‐Vilaseca, Marta; Pegueroles, Jordi; Rami, Lorena; Lladó, Albert; Luís Molinuevo, José; Tainta, Mikel; Clarimón, Jordi; L. Spires‐Jones, Tara; Blesa, Rafael; Fortea, Juan; Martínez‐Lage, Pablo; Sánchez‐Valle, Raquel; Sabidó, Eduard; Bayés, Àlex; Belbin, Olivia

doi:10.1074/mcp.ra118.001290

Public

Changes in Synaptic Proteins Precede Neurodegeneration Markers in Preclinical Alzheimer's Disease Cerebrospinal Fluid

Published in Molecular & Cellular Proteomics • Jan 3, 2019

Authors:

Alberto Lleó

Raúl Núñez‐Llaves

Daniel Alcolea

Abstract

In the search for biomarkers of synapse loss associated with Alzheimer's disease (AD), we used shotgun proteomics to identify a panel of 9 synaptic proteins detectable in human cerebrospinal fluid (CSF). Expression at the human synapse was verified using super resolution microscopy. Using SRM, we mo...

Subject

Biomarker

Proteomics

Cerebrospinal fluid

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