<i>Dnase1l3</i> deletion causes aberrations in length and end-motif frequencies in plasma DNA

Serpas, Lee; W.Y. Chan, Rebecca; Jiang, Peiyong; Ni, Meng; Sun, Kun; Rashidfarrokhi, Ali; Soni, Chetna; Sisirak, Vanja; Lee, Wing‐Shan; Hang Cheng, Suk; Peng, Wenlei; Allen Chan, K.C.; W. K. Chiu, Rossa; Reizis, Boris; Ming Dennis Lo, Yuk

doi:10.1073/pnas.1815031116

Public

Dnase1l3 deletion causes aberrations in length and end-motif frequencies in plasma DNA

Published in Proceedings of the National Academy of Sciences • Dec 28, 2018

Authors:

Lee Serpas

Rebecca W.Y. Chan

Peiyong Jiang

Abstract

Circulating DNA in plasma consists of short DNA fragments. The biological processes generating such fragments are not well understood. DNASE1L3 is a secreted DNASE1-like nuclease capable of digesting DNA in chromatin, and its absence causes anti-DNA responses and autoimmunity in humans and mice. We ...

Subject

DNA

DNA fragmentation

Biology

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