Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial

Matas, José; Orrego, Mario; Amenábar, Diego; Infante, Catalina; Tapia‐Limonchi, Rafael; I. Cádiz, María; Alcayaga‐Miranda, Francisca; L. González, Paz; Muse, Emilio; Khoury, Maroun; Figueroa, Fernando; Espinoza, Francisco

doi:10.1002/sctm.18-0053

Public

Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial

Published in Stem Cells Translational Medicine • Dec 28, 2018

Authors:

José Matas

Mario Orrego

Diego Amenábar

Abstract

Abstract Knee osteoarthritis (OA) is a leading cause of pain and disability. Although conventional treatments show modest benefits, pilot and phase I/II trials with bone marrow (BM) and adipose-derived (AD) mesenchymal stromal cells (MSCs) point to the feasibility, safety, and occurrence of clinical...

Subject

Medicine

WOMAC

Mesenchymal stem cell

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