Profibrotic effect of IL-17A and elevated IL-17RA in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated lung disease support a direct role for IL-17A/IL-17RA in human fibrotic interstitial lung disease

Zhang, Jie; Wang, Dan; Wang, Lei; Wang, Shaohua; C. Roden, Anja; Zhao, Hao; Li, Xiujuan; S. Prakash, Y.; L. Matteson, Eric; J. Tschumperlin, Daniel; Vassallo, Robert

doi:10.1152/ajplung.00301.2018

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Profibrotic effect of IL-17A and elevated IL-17RA in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated lung disease support a direct role for IL-17A/IL-17RA in human fibrotic interstitial lung disease

Shared by NobleBlocks on Mar 1, 2019 • 12:00 AM UTC

Authors:

Jie Zhang

Dan Wang

Lei Wang

Abstract

Interleukin (IL)-17 is a T helper 17 cytokine implicated in the pathogenesis of many autoimmune diseases, including rheumatoid arthritis (RA). Although IL-17A has a well-established role in murine pulmonary fibrosis models, its role in the tissue remodeling and fibrosis occurring in idiopathic pulmo...

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