Mitochondrion-targeted platinum complexes suppressing lung cancer through multiple pathways involving energy metabolism

Zhu, Zhenzhu; Wang, Zenghui; Zhang, Changli; Wang, Yanjun; Zhang, Hongmei; Gan, Zhenji; Guo, Zijian; Wang, Xiaoyong

doi:10.1039/c8sc04871a

Public

Mitochondrion-targeted platinum complexes suppressing lung cancer through multiple pathways involving energy metabolism

Shared by NobleBlocks on Jan 1, 2019 • 12:00 AM UTC

Authors:

Zhenzhu Zhu

Zenghui Wang

Changli Zhang

Abstract

Monofunctional platinum complexes restrain lung cancer through disrupting mitochondrial oxidative phosphorylation and glycolysis in addition to damaging nuclear and mitochondrial DNA.

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