PROREPAIR-B: A Prospective Cohort Study of the Impact of Germline DNA Repair Mutations on the Outcomes of Patients With Metastatic Castration-Resistant Prostate Cancer

Castro, Elena; Romero-Laorden, Nuria; del Pozo, Ángela; Lozano, Rebeca; Medina, Ana; Puente, Javier; M. Piulats, Josep; Lorente, David; Sáez, M.I.; Morales‐Barrera, Rafael; González‐Billalabeitia, Enrique; Cendón, Ylenia; García-Carbonero, I.; Borrega, Pablo; Méndez Vidal, M.J.; Montesa, A.; Nombela, Paz; Fernández-Parra, E.; González del Alba, Aranzazu; Carlos Villa-Guzmán, José; Ibáñez, Kristina; Rodríguez‐Vida, Alejo; Magraner-Pardo, Lorena; Pérez‐Valderrama, Begoña; Vallespín, Elena; Gallardo, Enrique; Vázquez‐Estévez, Sergio; C. Pritchard, Colin; Lapunzina, Pablo; Olmos, David

doi:10.1200/jco.18.00358

Public

PROREPAIR-B: A Prospective Cohort Study of the Impact of Germline DNA Repair Mutations on the Outcomes of Patients With Metastatic Castration-Resistant Prostate Cancer

Published in Journal of Clinical Oncology • Jan 9, 2019

Authors:

Elena Castro

Nuria Romero-Laorden

Ángela del Pozo

Abstract

PURPOSE: Germline mutations in DNA damage repair (DDR) genes are identified in a significant proportion of patients with metastatic prostate cancer, but the clinical implications of these genes remain unclear. This prospective multicenter cohort study evaluated the prevalence and effect of germline ...

Subject

Medicine

PALB2

Prostate cancer

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