USP5 promotes epithelial-mesenchymal transition by stabilizing SLUG in hepatocellular carcinoma

Meng, Jing; Ai, Xiaoyu; Lei, Yue-Yang; Zhong, Weilong; Qian, Baoxin; Qiao, Kailiang; Wang, Xiaorui; Zhou, Bijiao; Wang, Hongzhi; Huai, Longcong; Zhang, Xiaoyun; Han, Jingxia; Xue, Yinyin; Liang, Yuan; Zhou, Honggang; Chen, Shuang; Sun, Tao; Yang, Cheng

doi:10.7150/thno.27654

Public

USP5 promotes epithelial-mesenchymal transition by stabilizing SLUG in hepatocellular carcinoma

Published in Theranostics • Jan 1, 2019

Authors:

Jing Meng

Xiaoyu Ai

Yue-Yang Lei

Abstract

Our findings reveal that USP5 serve as a potential target for tumor intervention and provide a preliminary antitumor therapy for inhibit EMT by targeting USP5 or its interaction with SLUG in HCC.

Subject

Slug

Epithelial–mesenchymal transition

Deubiquitinating enzyme

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